Central Asia, with its rich history and multinational composition, remains a key region in terms of geopolitics and national security for Kazakhstan. The evolution of political thought in this region has a direct impact on internal and external political processes. This article examines the evolution of political thought and the main challenges faced by Central Asia, as well as the prospects for cooperation to ensure the national security of Kazakhstan. The authors analyze the variety of challenges faced by the countries of the region, including religious radicalism, interethnic conflicts and geopolitical dynamics of cooperation with other states. The changes in the political environment of Central Asia after the change of political regimes in some countries are analyzed. The article emphasizes the need for an in-depth analysis of political processes to ensure stability and national security in the region.